Minisatellite instability is found in colorectal tumours with mismatch repair deficiency
نویسندگان
چکیده
منابع مشابه
APC mutations in colorectal tumors with mismatch repair deficiency.
We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this step in neoplastic transformation. However, in a total of 101 sequenced mutations, we noted a subs...
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Colorectal cancers associated with Lynch syndrome are characterized by deficient DNA mismatch repair (MMR) function. Our aim was to evaluate the prevalence of microsatellite instability (MSI) and loss of MMR protein expression in Lynch syndrome-associated polyps. Sixty-two colorectal polyps--37 adenomatous polyps, 23 hyperplastic polyps, and 2 sessile serrated polyps (SSP)--from 34 subjects wit...
متن کاملFrequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer.
BACKGROUND The incidence of colorectal cancer in persons under 46 years of age is substantially higher in Hong Kong than in Scotland and many other countries. Consequently, we examined whether there is a hereditary predisposition for colorectal cancer in this Southern Chinese population. METHODS We investigated the incidence of microsatellite instability (MSI) at 10 DNA sites in 117 colorecta...
متن کاملIrinotecan and mismatch repair deficiency.
We read the recent publications of Ychou et al. [1, 2] on ‘adjuvant’ irinotecan-based chemotherapy in high-risk localized colorectal cancer (CRC) and after resection of liver-confined metastatic disease with great interest. In contrast to the improved outcome provided by oxaliplatin-based adjuvant treatment of early-stage disease, there is now a body of evidence showing that the addition of iri...
متن کاملDNA Mismatch Repair Deficiency in Colorectal Adenocarcinoma and its Association with Clinicopathological Features
Background: Evaluation of mismatch repair (MMR) status in colorectal cancer (CRC) could be used as the guidance for postsurgical treatment. Defective MMR status is associated with distinct clinicopathological features. This study aims to evaluate associations between MMR status and clinicopathological features in a retrospective cohort of consecutive Chinese CRC patients. Methods: Clinicopathol...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2001
ISSN: 0007-0920,1532-1827
DOI: 10.1054/bjoc.2001.2058